I've been using the .NET version of FCKeditor for some time, but recently changed the page layout, resulting in the FCKeditor instance now residing in an AJAX UpdatePanel. All was fine while using IE, but when I tested it in Firefox I noticed that the changed content in the FCKeditor wasn't getting saved to the database. It turns out its a JavaScript issue that effects Firefox and Safari.

I've been unable to find the perfect solution but in the meantime I discovered the following code does the trick - but unfortunately causes Firefox/Safari users to see a full post back - not just what's in the UpdatePanel.

if (Request.Browser.Browser.ToLower().Contains("firefox") || Request.Browser.Browser.ToLower().Contains("safari"))
        {
            ScriptManager sm = Master.FindControl("ScriptManager1") as ScriptManager;
            sm.RegisterPostBackControl(btnMySubmitButton);
        }

If anyone knows a better way to fix it please let me know!